Integrating Pathways of Parkinson’s Disease in a Molecular Interaction Map

K. A. Fujita, M. Ostaszewski, Y. Matsuoka, S. Ghosh, E. Glaab, C. Trefois, I. Crespo, T. M. Perumal, W. Jurkowski, P. M. A. Antony, N. Diederich, M. Buttini, A. Kodama, V. P. Satagopam, S. Eifes, A. del Sol, R. Schneider, H.Kitano, R. Balling

Molecular Neurobiology, Volume 49, Issue 1, Page 88-102

Parkinson’s disease (PD) is a major neurodegenerative chronic disease, most likely caused by a complex interplay of genetic and environmental factors. Information on various aspects of PD pathogenesis is rapidly increasing and needs to be efficiently organized, so that the resulting data is available for exploration and analysis. Here we introduce a computa- tionally tractable, comprehensive molecular interaction map of PD. This map
integrates pathways implicated in PD pathogen- esis such as synaptic and mitochondrial dysfunction, impaired protein degradation, alpha-synuclein pathobiology and neuroinflammation. We also present bioinformatics tools for the analysis, enrichment and annotation of the map, allowing the research community to open new avenues in PD research. Full text PDF Publisher