The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson’s Disease

Pauline Mencke, Ibrahim Boussaad,Chiara D. Romano, Toshimori Kitami,Carole L. Linster and Rejko Krüger

Cells, February 2021, 10(2), 347. https://doi.org/10.3390/cells10020347

Abstract

DJ-1 is a multifunctional protein associated with pathomechanisms implicated in different chronic diseases including neurodegeneration, cancer and diabetes. Several of the physiological functions of DJ-1 are not yet fully understood; however, in the last years, there has been increasing evidence for a potential role of DJ-1 in the regulation of cellular metabolism. Here, we summarize the current knowledge on specific functions of DJ-1 relevant to cellular metabolism and their role in modulating metabolic pathways. Further, we illustrate pathophysiological implications of the metabolic effects of DJ-1 in the context of neurodegeneration in Parkinson´s disease.

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