PROJECTS

Biospecimen Research

Topic  

Partners

Cell counting method comparison

National Institute of Standards and Technology (NIST)

Impact of slide waxing on extracted nucleic acids

Breast International Group (BIG), Imperial College London (ICL)

CSF freeze drying and fitness-for-purpose for metabolomics and proteomics

Luxembourg Centre for Systems Biomedicine (LCSB)

DNA extraction from FFPE tissue and fitness-for-purpose for NGS

Private pathology laboratory in Thionville

Evaluation of a new blood collection tube

Becton Dickinson

Urine stability study Internal project
Impact of vacuum drying on extracted nucleic acids Internal project
Evaluation of fully automated method for DNA extraction from FFPE tissue ICL
CSF processing and inter-laboratory reproducibility Erlangen University Hospital
CSF qualification VU University Medical Center
Impact of cold ischemia time on tissue mRNA International Society for Biological and Environmental Repositories (ISBER) Biospecimen Science Working Group, National Cancer Institute (NCI) 
RNA and miRNA stability in FFPE tissue ICL, Wales Cancer Bank
Impact of physicochemical factors on tissue miRNA Denator, Wafergen Biosystems (Takara)
Interactive protocol project for simultaneous DNA, RNA and protein extraction from tissue ICL, Beaumont Biobank
Impact of Proteinase K digestion on DNA extraction from FFPE tissue ICL
Formalin contamination of tissue processors Internal project
Research and validation of micro- and macro-molecular biomarkers for the quality of preservation of biological samples, and the validation of the related methods International Society for Biological and Environmental Repositories (ISBER) Biospecimen Science Working Group
Stool metabolite stability Biocrates
Microbiome reference materials Internal project
Stool collection tube comparison LUXIA

 

Diabetes

TOPIC PARTNERS
Colonisation, Succession and Evolution of Human Gastrointestinal MICrobiome from Birth to Infancy (COSMIC) LCSB : Eco-Systems Biology, Science for Life Laboratory, Centre Hospitalier de Luxembourg (CHL)
Innovative approach towards understanding and arresting type 1 diabetes (INNODIA) Innovative Medicines Initiative 2 (IMI2)

Cancer

TOPIC PARTNERS
Lung Cancer Study (LCS) Luxembourg Institute of Health  (LIH), Partnership for Personalised Medicine, CHL
Biomarker discovery & validation in lung cancer LIH, Personalised Medicine Consortium (PMC)
Collection of skin biopsies for establishment of melanoma cell lines University of Luxembourg (Uni.lu)
Discovery of new therapeutic targets for colorectal cancer (SOCS) Laboratoire National de Santé (LNS), Uni.lu, LIH, Hôpitaux Robert-Schuman (HRS), Centre Hospitalier Emile Mayrisch (CHEM), CHL
Cancer treatment and monitoring through identification of circulating tumour cells and tumour related nucleic acids (Cancer-ID) Bayer AG, University Hospital Hamburg-Eppendorf, University of Twente, Menarini Silicon Biosystems
Tumorothèque Thionville (THION2) Private pathology laboratory in Thionville
Plan Cancer Collection (PKC) CHEM, CHL, Centre Hospitalier du Nord (CHdN), HRS, LNS
Non-invasive microbiome derived multiomic biomarkers for early stage colorectal cancer detection (MiCa) CHEM, CHL, European Molecular Biology Laboratory (EMBL), German National Center for Tumor Diseases Heidelberg (NCT), LCSB, University Hospital Heidelberg (UHH), Uni.lu
Adoption of personalised medicine and molecular diagnostics in Luxembourg (MDLUX2) Institut National du Cancer (INC)
The implementation of a personalized screening tool for pre- and probiotic interventions in colorectal cancer patients (PerPreProBioCRC) LCSB, PMC
Role of MiR-371-373 cluster in tumor initiation and metastatic colonization (MiRMet) Uni.lu
Biobanking of blood, breast tissue and tumour in Luxembourg: a pilot study (3B) CHL

Population studies

TOPIC PARTNERS
Collection of control biological samples from the population Zitha Gesondheetszenter (ZithaKlinik, HRS)
Applying systems immunology to the search for personalised biomarkers of clinical efficacy LIH
European Health Examination Survey (EHES) extended with local component EHES, LIH, Ministry of Health
Second observational study of cardiovascular risk factors in the general population in Luxembourg (ORISCAV II) Ketterthill Laboratories, LIH

Parkinson’s disease

TOPIC PARTNERS
BIOMARKAPD – Biomarkers for Alzheimer’s and Parkinson’s disease. A project within the EU Joint Programme for Neurodegenerative Diseases (JPND) European Joint Programme for Neurodegenerative Disease Research (JPND) consortium members
Advanced modelling of Parkinson’s disease with three-dimensional human midbrain organoids LCSB
Metabolomics & neuronal imaging in PD (METIMAGPD)  LCSB, Uniklinik Köln
Biomaterial collection for neurodegenerative disease research (ND Collection) in the framework of the National Centre for Excellence in Research on Parkinson’s Disease (NCER-PD) programme CHL, Fonds National de la Recherche (FNR), LCSB, LIH
Development of a multifactorial biomarker signature for the diagnosis of motor- phase and prodromal Parkinson’s disease (DIAGNOSIS) in the framework of the National Centre for Excellence in Research on Parkinson’s Disease (NCER-PD) programme CHL, FNR, LCSB, LIH
A deep phenotyping approach for comprehensive genetic stratification of therapy outcomes for deep brain stimulation in Parkinson’s disease (Earlystim Subproject Genetic Stratification) LCSB, EARLYSTIM partners

Contracts & others

TOPIC PARTNERS
Biospecimen Proficiency Testing ISBER and other organisations
Epilepsy sample storage LIH
Logistics, storage and supplies management for an international clinical trial CHL, LIH, Helsingborg Hospital, Lund University
Long term commercial storage contract for 52,000 samples from a completed European cancer trial European Organisation for Research and Treatment of Cancer (EORTC), BIG, Institut Bordet
Pathology processing for the Luxembourg arm of the AURORA breast cancer trial LARA BIG, CHL, LIH
PBMC isolation Gritstone Oncology
PBMC isolation and shipment services for a clinical trial UniQure
23 projects for PBMC isolation and shipment services for clinical trials Precision for Medicine
Sample storage for 2 ongoing European breast cancer trials BIG
Service agreement for sample storage and DNA extraction among others Uni.lu
Storage of iPS cell lines LCSB
Transfer of completed pharmaceutical trial samples to IBBL EORTC
Liver Investigation: Testing Marker Utility in Steatohepatitis (LITMUS) 47 LITMUS Consortium members including academic and industrial partners
DNA extraction from stool samples, DNA quantification and 16S Institute of Cardiometabolism And Nutrition (ICAN)
Tissue cassette printing East West Bio
IHC for ALK protein on Melanoma samples Uni.lu
Plan national maladies rares Codification Registre Recherche MR Ministry of Health , LIH, LNS, CNS
Plasma supply to Freenome-CRC and healthy (Freenome) Freenome

 

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